Tuesday, December 6, 2016

Rheumatoid arthritis (RA) is a systemic, inflammatory, and autoimmune disorder. Gut microbiota play an important role in the etiology of RA. With the considerable progress made in next-generation sequencing techniques, the identified gut microbiota difference between RA patients and healthy individuals provides an updated overview of the association between gut microbiota and RA. We reviewed the reported correlation and underlying molecular mechanisms among gut microbiota, the immune system, and RA.

It has become known that gut microbiota contribute to the pathogenesis of RA via multiple molecular mechanisms.

The progressive understanding of the dynamic interaction between gut microbiota and their host will help in establishing a highly individualized management for each RA patient, and achieve a better efficacy in clinical practice, or even discovering new drugs for RA.

Frå DENNE forskningsartikkelen. Med ein haug med referansar.
The second paper, published in Arthritis and Rheumatology, explored another facet of gut bacteria. Dr. Taneja treated one group of arthritis-susceptible mice with a bacterium, Prevotella histicola, and compared that to a group that had no treatment. The study found that mice treated with the bacterium had decreased symptom frequency and severity, and fewer inflammatory conditions associated with rheumatoid arthritis. The treatment produced fewer side effects, such as weight gain and villous atrophy -- a condition that prevents the gut from absorbing nutrients -- that may be linked with other, more traditional treatments.

While human trials have not yet taken place, the mice's immune systems and arthritis mimic humans, and shows promise for similar, positive effects. Since this bacterium is a part of healthy human gut, treatment is less likely to have side effects, says study co-author Joseph Murray, M.D., a Mayo Clinic gastroenterologist.

Frå denne forskningsoppsummeringa.
Jose Scher, MD, a rheumatologist at New York University Langone Medical Center, studies the connection between intestinal bugs and arthritis. He thinks the overgrowth of normally benign bacteria called Prevotella – which are far more abundant in people with untreated RA – may trigger an inflammatory response that targets the joints. It’s also possible Prevotella crowds out beneficial bacteria that keep inflammation in check. Either way, Scher is confident there’s a connection between the microbiome and arthritis.

...

One of the hottest questions right now is whether it will be possible to treat arthritis and other diseases by adjusting the microbiome. A growing number of scientists think so.

Writing in a review article published in the March 2016 issue of Current Opinion in Rheumatology, researchers from the University of Glasgow in the UK noted that “interventions targeting the microbiota may become therapeutically viable for some types of inflammatory arthritis.”

That idea is echoed by Martin Blaser, MD, a microbiologist at New York University Langone Medical Center and a widely respected microbiome expert.

“This is a fertile area for research because we know that particular microbes talk to human physiology in different ways with different vocabularies. As our understanding of this relationship grows, we may use it to regulate disease,” he says.


Frå denne artikkelen.
Bilderesultat for fauda

Fauda. På Netflix. DRITbra serie.

Monday, December 5, 2016

Recent neurobiological insights into this gut–brain crosstalk have revealed a complex, bidirectional communication system that not only ensures the proper maintenance of gastrointestinal homeostasis and digestion but is likely to have multiple effects on affect, motivation and higher cognitive functions, including intuitive decision making.

Moreover, disturbances of this system have been implicated in a wide range of disorders, including functional and inflammatory gastrointestinal disorders, obesity and eating disorders.

Emeran Mayer, Prof på UCLA. HER.
Indeed, emerging data suggest communication between the gut and the brain in anxiety, depression, cognition, and autism spectrum disorder (ASD). The development of a healthy, functional brain depends on key pre- and post-natal events that integrate environmental cues, such as molecular signals from the gut. These cues largely originate from the microbiome, the consortium of symbiotic bacteria that reside within all animals.

Frå denne artikkelen, av forskarar på CalTech.

Sunday, December 4, 2016



Elskar denne songen.


Ho her er utdanna lege, har doktorgrad i nevrologi, og mastergrad i tillegg. Ho står bak den kjente "GAPS"-dietten, som handlar om å ete sunt for å styrke immunforsvaret.

Det ho seier her om autoimmune sjukdomar er kjempeinteressant, og så langt eg kan døme i nær kontakt med den seriøse forskninga. Ho peikar på ulike mekanismar for utvikling av ulike autoimmune sjukdomar. Når det gjeld RA, peikar ho på at giftige avfallsstoff i tarmen kjem ut i kroppen, og desse har lett for å knyte seg til kollagen, som er eit elastisitetsprotein i ledda. Dermed angrip kroppen kollagenet som er infisert. Ho anbefalar alt det som Blum og co anbefaler: Å endre bakteriekulturen og "seal the gut", dvs. sørge for at inflammatoriske tilstandar som aukar gjennomtrenginga i tarmveggen, vert minska.

Mercola får kvar tenke kva ein vil om; han er skulemedisiner, men også open for mykje holistisk, så her er det vel berre å bruke hovudet.




Her er meir. Det er berre ekstremt tankevekkande å sjå henne fortelje at nær 100% av pasientane hennar som ho behandla for nevrologiske problem, også hadde fordøyingsproblem. Og skulemedisinen anerkjente ikkje nokon samanheng den gongen. Det vart sett som tilfeldig. Men no er jo forskninga der, frå dei beste universiteta, som peikar utvetydig på samanhengen. (Mykje forskning gjenstår, mykje kan reviderast etc. Men ja). Har ikkje sett heile filmen, går ikkje nødvendigvis god for alt her etc., men den som vil, kan sjå.


Saturday, December 3, 2016

The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health by [Sonnenburg, Justin, Sonnenburg, Erica]

Takk til Heidi for tipset. Anar ikkje kva eg har i vente her. MEN forfattarane er hhv prof og forskar på Stanford. Boka anbefalast av med. prof. på Harvard, samt ein leiar på Duke Univ, OG funksjonell medisin kjendisar. Verkeleg interessant samling av blurbs.



Og DETTE seier: Sonneburg, i intervju med Chris Kresser:


So really the gut microbiota, I think, can be thought of as a control center for so much of our biology, and by far, I would say, to this point, the most important facet of our biology that’s impacted by this microbial community is our immune function, again, certainly in the intestine, but throughout our body, how likely we are to fight off a respiratory infection, how quickly an autoimmune disease in our central nervous system progresses, how we respond to vaccination, all of these things are impacted by what our gut microbes are doing. That means that because the gut microbiota is malleable, because it changes day to day and we can affect it through what we eat, that means we have an incredible lever on many aspects of our biology, including how our immune system functions.




You mentioned chronic diseases, and I think that there’s a major connection between what’s going on in our gut microbiota and inflammation, which occurs at various sites throughout our body. We know that it’s inflammation that drives many of these chronic diseases, and so that’s probably a really fundamental important connection.


Meir cutting-edge forskning som knyter mage og tarm til Parkinson. Nokon slags fiber frå magen transporterast langs nervene og oppover til hjernen, og skadar dei indre delane av hjernen. Les HER. Ved museforsøk ved RA, og ved museforsøka til Parkinson, er problemet at patogene bakteriar (ved infeksjon) skaper toksiner, som skadar kroppen, når dei sleppast laus i kroppen. Den førre artikkelen eg linka til, skriv at det er avgjerande kva generell mageflora ein har. Det peikast også på at forstoppelse kan vere ei slags varsellampe. I det heile er det meir og meir evidence som peikar mot at mageflora er ekstremt viktig for utviklinga av ei mengd med sjukdomar.